Western Medicine Primer

Modern allopathic dermatology plants itself in evidence-based medicine.

Western overview of skin and western skin schematic

Modern medicine is a combination of many different disciplines such as genetics, anatomy, biochemistry, pathology, microbiology, immunology, nutrition, pharmacology, epidemiology and many others. These various disciplines are brought together and focus on human health, disease, and treatment of disease. Allopathic dermatology is a specialized field of medicine and utilizes all the disciplines above. An overview of the skin is shown with the functions of the various parts of the skin.

Modern allopathic dermatology plants itself in evidence-based medicine. This means that dermatologists try to the best of their ability to make decisions that are based on some proof. The proof is usually in the form of experiments (often referred to as studies or trials) that involve real people that have the condition of interest (such as acne, eczema etc.). This way of thinking about disease and treatment is rooted in the basic scientific method that requires tangible and objective proof. So for example, if a doctor treats a skin infection (such as folliculitis) with antibiotics, it is because they based their decision on other similar patients that had this condition and improved with antibiotics. Additionally, they can show you other cases in which the infection resolved when treated with antibiotics. Sounds like good proof? Yes, but allopathic dermatology does not stop there. Dermatologists typically ask for evidence from clinical studies, especially randomized clinical trials. These types of trials evaluate the results of the treatment when compared to other common treatments or a placebo (sugar pill for example). These trials randomly assign the two different treatments based on a coin flip. This random assignment helps to reduce (as much as possible) any bias in the study to accurately tell if a patient heals due to the treatment and not some other effect. In the previous example a randomized study may compare the antibiotics to a placebo (or different antibiotic) and if we find that the infection resolved faster in the antibiotics group we can conclude that antibiotics help skin infection. This is the type of rigorous evaluation dermatologists expect to have for every treatment they prescribe or diagnostic test they order.  Unfortunately, that level of proof (i.e. randomized trials) is not always available but as additional research is conducted, more and more evidence becomes available. 

 

What Do Dermatologists Do?

A common misconception that dermatologists face daily is that they only deal with acne, cosmetic treatments, and skin rashes. This is a very incomplete understanding of what dermatologists do. Dermatology covers not only the skin but also the hair, nails and mucus membranes (i.e. the wet part of a body's various orifices, such as mouth, eyes, and genitalia). Another striking and less known fact about dermatology is that it involves a huge amount of different medical diagnoses. Indeed, the vast majority of the diagnoses dermatologists deal with on a daily basis are never taught in medical school! This makes dermatologists highly skilled doctors.

 

How Does a Dermatologist Make a Diagnosis?

Like every other physician, dermatologists need to hear the patient's story about the problem, They can order various blood tests, cultures, biopsies and imaging (like x-ray, MRI, CT etc.). However what is very unique about dermatology is the physical exam. Because the skin is the only organ in the body that is entirely available to be viewed “on the outside”, dermatologists can appreciate many subtleties of the disease simply by…looking! This is very different than ANY other medical specialty. An ophthalmologist is unable to remove an eye from its socket, examine it and then put it back… by the same token, a pulmonologist, gastroenterologist or cardiologist cannot take out the lungs, gut or heart. This will be even harder for a psychiatrist.

Therefore, the dermatologist on first encounter will ask a patient to completely undress for a full examination. While this may be uncomfortable and time-consuming for the patient, this is the single most important part of the dermatologist’s work and there is no other specialist, allopathic or alternative,  that can provide this service. A dermatologist can save lives with early identification of diseases such as skin cancer. 

 

What Do Dermatologists Look at When They Examine the Skin?

Dermatologists look at the pattern of the rash (also known as distribution and configuration). Patterns can be very telling since it turns out particular rashes appear to have consistent patterns from one person to another. These patterns often derive from structures under the skin (blood vessels, nerves etc.). One classic example is shingles (zoster) which follows a branch of the nerves and therefore will look linear, like a branch. Knowing the patterns of disease is very helpful because some rashes can change colors as well as other typical features and it is the pattern that can help to make the diagnosis.

Rashes can also be broken down to what is the actual basic lesion that makes up the whole rash (the so-called primary lesion). This is very important because often all that is left from the rash are dark spots and by the time the patient comes to the dermatologist the rash looks completely different. This is very frustrating! Only knowledge of the primary lesion can help the dermatologist make a diagnosis. So for example eczema and psoriasis can both resolve with residual brown spots yet knowing what the rash looked like originally will lead to different treatment plans. Sometimes snapping a picture of a rash when it first appears can make a world of a difference for the dermatologist. Having a patient take out their phone and snap an image can be a beneficial tool for diagnostics. 

Dermatologists always look at colors of the rash. Amazingly the skin is able to produce a wide spectrum of colors: red often means blood under the skin suggesting inflammation or bleeding. Brown is typically a result of a pigment molecule called melanin. We all come in different colors and that has to do with the amount of melanin and how it is distributed in our skin. However, sometimes brown is just broken down blood. The color blue in the skin can mean a collection of venous blood or deeper pigment. And the list goes on and on…purple, yellow, orange, white, black even green and pink are all colors that our skin can produce in health or disease.

Much like a good detective, the dermatologist puts all the clues together and makes a diagnosis.

 

Many Rashes Are Benign so Why Should You Care About Them?

Probably the coolest part about dermatology is the case where the skin is a reflection of an internal disease. Sometimes acne occurs in the setting of a condition called polycystic ovary syndrome (PCOS).[2] PCOS can result in difficulty becoming pregnant. Amazingly a dermatologist can make this diagnosis without a single blood test – simply by looking! Another example is itch. Often itch is a result of elevated toxin in the body due to liver or kidney disease.[3]Rarely, itch can be a sign of a type of cancer called non-Hodgkins lymphoma as well as other cancers [3] and that itch may be the only clue to making the diagnosis! There are many other associations, psoriasis and arthritis, lichen planus (itchy rash) and hepatitis, [4] and the list goes on and on.

 

The Modern Doctor’s Two Best Friends

Many people have had the experience of having a doctor order and test, get a positive result, and be told that he or she is not sure if they have the disease. Others may have been told that they may have one of five diseases. These scenarios occur every day in modern allopathic medicine and can be very frustrating. Patients may find themselves asking "Why can’t a test just tell me if I have the disease? Why can’t the doctor just give me a “bottom line” diagnosis?" The main reason for this is that modern medicine is practiced with a certain amount of uncertainty and ambiguity. The reason for that is that we simply do not know everything there is to know about the human body, nor do we understand every aspect of disease. For example, we don’t really fully understand what causes rosacea (a common skin condition that gives people red faces). Despite many attempts, no one has been able to prove that a single problem (e.g. a virus or an enzyme defect) leads directly to rosacea.[5]  This gets even more complicated when it comes to various medical tests. The reason is that most tests are only surrogates of the disease. And so even if you obtain a skin biopsy from a suspicious mole, you may never know for sure if you are dealing with a tumor that is harmless or one that may turn to a nasty melanoma. That is because a skin biopsy only examines a small part of the entire lesion and even if all of the cells appear normal, you can’t pull all of them out and ask them: “are you a melanoma cell? Did you already send metastatic disease to the liver?”  So how is a person expected to trust their dermatologist? Once again, it comes down to the patient and doctor getting cozy and comfortable with the modern doctor’s two best friends:  uncertainty and ambiguity. Most of the time, doctors have a good idea about a diagnosis and a good guess of how a patient may respond to treatment. But because of all the reasons above, nothing is a hundred percent. It is very important for patients to have an honest and open discussion with their doctor about how confident they are with the diagnosis and about the various advantages and risks of the treatment options. This type of approach will help the patient deal with the uncertainty and make seeing a doctor a more positive experience.

* This Website is for general skin beauty, wellness, and health information only. This Website is not to be used as a substitute for medical advice, diagnosis or treatment of any health condition or problem. The information provided on this Website should never be used to disregard, delay, or refuse treatment or advice from a physician or a qualified health provider.

References

1.            Kingsley-Loso JL, Grey KR, Hanson JL, et al. Incidental lesions found in veterans referred to dermatology: the value of a dermatologic examination. J Am Acad Dermatol.2015;72(4):651-655 e651; PMID: 25619205.

2.            Housman E, Reynolds RV. Polycystic ovary syndrome: a review for dermatologists: Part I. Diagnosis and manifestations. J Am Acad Dermatol.2014;71(5):847 e841-847 e810; quiz 857-848; PMID: 25437977.

3.            Fett N, Haynes K, Propert KJ, et al. Predictors of malignancy development in patients with chronic pruritus. J Dermatol Sci.2016;10.1016/j.jdermsci.2016.01.010PMID: 26874971.

4.            Garcovich S, Garcovich M, Capizzi R, et al. Cutaneous manifestations of hepatitis C in the era of new antiviral agents. World J Hepatol.2015;7(27):2740-2748; PMID: 26644817.

5.            Two AM, Wu W, Gallo RL, et al. Rosacea: part I. Introduction, categorization, histology, pathogenesis, and risk factors. J Am Acad Dermatol.2015;72(5):749-758; quiz 759-760; PMID: 25890455.