The Science of Psoriatic Disease: A Foundation for the Clinic

Course Overview

Preview what you'll learn in this program

Apr 2024

Released

What You'll Learn

Psoriasis is a complex, heterogeneous inflammatory disease characterized by thickened, red, scaly plaques and systemic inflammation that include the joints and the cardiovascular system. Multiple signaling pathways appear to modulate this inflammatory disease with development of efficacious topical, oral, and injectable therapies. This lecture will summarize the role of IL-17/23, the JAK and TYK2 pathway, phosphodiesterase 4 receptor, aryl hydrocarbon receptor, retinoid receptors, vitamin D receptors, calcineurin inhibitors, and steroids in the modulation of psoriasis.

Learning Objectives:

Participants will review the epidemiology, genetic, clinical variations, pathogenic features, and immune pathways contributing to psoriatic disease.
Participants will diagram the pathophysiology of psoriasis, including the role of TNF, IFN, IL-17A, IL-17F, IL-23, TYK2, AhR, JAK-STAT, and PDE4 signaling pathways.
Participants will summarize the specific mechanisms of action for the available topical, systemic, and biologic agents used to manage psoriatic disease.

Faculty

Jason Ezra Hawkes

MD MS FAAD

Accreditation Information

Despite the rapid introduction of new systemic psoriasis treatments, topical therapies remain a mainstay strategy for mild to moderate psoriasis. Psoriasis treatments have historically heavily relied on topical steroids and several non-steroidal options will be discussed. Topical approaches for treating itch and inflammation will be discussed.

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