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Mary Brittain Blankenship, MD is the founder of Spruce MD Integrative Medicine in Greenville, SC. She is board certified in internal medicine and has experience in both hospital medicine and cardiovascular inpatient medicine. She received her medical degree from the University of South Alabama and completed a residency in internal medicine through the University of Utah. Through the Academy of Integrative Health and Medicine she completed an integrative medicine fellowship in 2018. Her medical interests include integrative approaches to treating chronic disease, athletic performance optimization, integrative Derm, and gut disorders. Outside of her clinic, Mary Brittain enjoys long-distance running, road and gravel biking, and traveling with her family. She is an avid cook, voracious reader

The market size for vitamins and supplements in the USA is currently at $36 bn, with trends anticipating growth in the next five years.1 Given that 15-30% of patients with depression experience therapy resistance to current standard therapies,2 the use of supplements for the treatment of these disorders may be an alternative solution for these patients. The following is an overview of the evidence concerning frequently used supplements for the treatment of depression and anxiety, either as monotherapy or in conjunction with pharmacological therapies.
