The health of the gut microbiome is increasingly being shown to be an important factor in health issues. Evidence points toward an intimate relationship of the gut-skin axis which demonstrates that gut dysbiosis plays a role in the pathogenesis of atopic dermatitis, psoriasis, acne and rosacea. Antibiotic use, poor diet, and stress can contribute to an imbalance of microbes living in the gut. By addressing gut dysbiosis, research suggests that skin health may improve. Interventions that may be helpful include: probiotics, prebiotics, diet, herbal/natural antimicrobials, gut supportive nutrients, digestive factors, and stress management. Addressing gut dysbiosis (even in the absence of clinical gut-related symptoms) gives physicians another potent tool to support their patients struggling with chronic conditions like atopic dermatitis, psoriasis, acne and rosacea.