Interactive Case Simulation: A 34-Year-Old Woman with Progressive Skin Depigmentation

Navigate a realistic patient case and make key diagnostic and treatment decisions for a newly diagnosed patient with moderate generalized vitiligo. Participants will assess disease severity, select appropriate phototherapy strategies, and evaluate the role of topical and systemic JAK inhibitors in early disease management.

The case also explores factors that influence outcomes, including predictors of repigmentation, nutritional deficiencies, and psychosocial stressors. Practical guidance on patient counseling, treatment expectations, and improving adherence will help learners apply evidence-based vitiligo care in clinical practice.


Learning Objectives:

• Recognize key clinical and dermoscopic features of new-onset nonsegmental vitiligo and interpret their prognostic implications.
• Explain the mechanisms and evidence supporting the use of narrowband UVB phototherapy and topical JAK inhibitors in the management of vitiligo.
• Identify appropriate nutrient deficiency screening and supplementation in vitiligo patients, and outline evidence-based dosing strategies.
• Discuss the role of psychological stress and oxidative pathways in vitiligo pathogenesis and describe integrative interventions to support emotional well-being.
• Set realistic patient expectations regarding treatment timelines, adverse event management, and predictors of successful repigmentation.