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While there are many different risk factors for developing atopic dermatitis (AD), filaggrin is one of the central players in the pathogenesis and severity of the disease. Filaggrin is a protein found in the epidermis critical to the formation of corneocytes and maintaining the epidermal barrier. While filaggrin gene (FLG) mutations are often the cause of reduced filaggrin, deficient levels of filaggrin are also found in AD patients without any FLG mutations. Preliminary research shows that L-histidine supplementation could increase filaggrin production and be a viable and safe part of an eczema treatment plan.
Dr. Julie Greenberg is a licensed Naturopathic Doctor (ND) and Registered Herbalist RH(AHG) who specializes in integrative dermatology. She is the founder of the Center for Integrative Dermatology, a holistic clinic that approaches skin and hair problems by finding and treating the root cause. Dr. Greenberg holds degrees from Northwestern University (BA), Stanford University (MBA) and Bastyr University (ND). Her research on the gut microbiome of acne patients has been published in a leading peer-reviewed clinical dermatology journal. While at naturopathic medical school, Dr. Greenberg received training with leading experts in dermatology at the University of Washington Medical School Dermatology Clinic and Seattle Children’s Hospital Pediatric Dermatology Clinic. She lectures at naturopathic medical schools and speaks at conferences across the U.S. on the topics of hair, skin and nails.
Dr. Peter Lio is a Clinical Assistant Professor of Dermatology and Pediatrics at the Northwestern University Feinberg School of Medicine. He received his medical degree from Harvard Medical School, completed his internship in Pediatrics at Boston Children's Hospital, and his Dermatology training at Harvard where he served as Chief Resident in Dermatology. Dr. Lio is the founding director of the Chicago Integrative Eczema Center and has spoken nationally and internationally about atopic dermatitis, as well as alternative medicine.
Dr. Raja Sivamani is a board-certified dermatologist and practices as an integrative dermatologist at Pacific Skin Institute. He is an Adjunct Associate Professor of Clinical Dermatology at the University of California, Davis and Director of Clinical Research and the Clinical Trials Unit.He is also an Adjunct Assistant Professor in the Department of Biological Sciences at the California State University, Sacramento and an Associate Professor of Dermatology at California Northstate University, College of Medicine.He engages in clinical practice as well as both clinical and translational research that integrates bioengineering, nutrition, cosmetics, and skin biology. With training in both Allopathic and Ayurvedic medicine, he takes an integrative approach to his patients and in his research.He has published over 100 peer-reviewed research manuscripts, 10 textbook chapters, and a textbook entitled Cosmeceuticals and Active Cosmetics, 3rd Edition with a passion for expanding the evidence and boundaries of integrative medicine for skin care.