This session will be a practical scientific review on the immunology of HS and the role of the local anatomy. The emerging role of the JAK/TEC and IL-17/23 pathways will be emphasized as an emerging understanding of the pathophysiology of this condition.

Learning Objectives:

  • Diagram the inflammatory signals that are upregulated and the role of the JAK/TEC and IL-17/23 pathways in driving the inflammation of HS
  • Describe the emerging therapeutic approaches for HS and how this influences the skin and hair follicles in typical sites of involvement


User: jfrew@mail.rockefeller.edu
John Frew

Dr. John Frew is a fellow of the Australasian College of Dermatologists and a globally recognized researcher in Hidradenitis Suppurativa. He completed his medical degree (with Honours) from the University of New South Wales in 2009, followed by a Masters of Medicine in clinical epidemiology from the University of Sydney in 2011, followed by completing his dermatology specialist training in 2016. Dr. Frew recently completed a highly competitive post-doctoral fellowship at the prestigious Rockefeller University in New York City between 2018-2020 (under the guidance of Professor James Krueger), identifying immunological pathways and novel therapies for the treatment of Hidradenitis Suppurativa. Dr. Frew has over 100 peer-reviewed publications and contributed to numerous dermatology and immunology textbooks. He currently holds a staff specialist position at Liverpool Hospital and is a conjoint lecturer at the University of New South Wales, supervising dermatology trainees and postgraduate research students.

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